Ag- and Sr-enriched nanofibrous titanium phosphate phases as potential antimicrobial cement and coating for a biomedical alloy

Biomaterials and their surfaces regulate the biological response ultimately quality of healing at a possible site implantation. The physical, chemical topographical properties implants' play decisive role in integration process for immediate loading long-term success. Since this level interaction nano-dimensionality is basically entailed, bio-functional nanostructured composites either as filling/cement or coating to metallic implants are required. This study shows possibility synthesizing two phases titanium phosphate (? ? polymorphs) enriching them with silver nanoparticles strontium. More importantly, Ag-Sr-enriched ??titanium induced grow on commercially available alloy (Ti-6Al-4V), widely used orthopedic dental implants, under highly controlled conditions. Structural microscopic studies, using XRD, HRTEM SEM altogether confirm resultant enrichment strontium an average particle size around 6 nm. Using confocal laser scanning microscopy, surface roughness was measured found lay interface between nanosized microsized topologies. Ion release assessments showed that presence rate ions could be beneficial terms decreasing accompanied cytotoxicity usually encountered high concentrations release. Antimicrobial cell proliferation assays have proved has improved antimicrobial properties, while controlled.